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During the 2021 TCT Meetings Digital Experience, the MPN Hub spoke to Craig W. Freyer, University of Pennsylvania, Philadelphia, US. We asked, How should conditioning be performed before transplanting a patient with MF?
How should conditioning be performed before transplanting a patient with MF?
Freyer overviews research on different conditioning regimens for patients with myelofibrosis (MF) prior to allogeneic stem cell transplant. This includes comparing outcomes and tolerability of myeloablative versus reduced intensity conditioning, finding the optimal treatment combination, and outlining early data for an intermediate intensity conditioning regimen.
What is the impact of pre-treatment ruxolitinib on patients with MF receiving allo-HSCT? An EBMT CMWP study
Most patients (89%) diagnosed with myelofibrosis (MF) present with splenomegaly, and new or increasing splenomegaly is considered to be a...
The role of inflammation in MPN and its therapeutic management
Myeloproliferative neoplasms (MPN) are a group of hematological malignancies characterized by aberrant clonal expansion of hematopoietic stem cells (HSCs) in the bone marrow (BM). This...
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