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Ropeginterferon-alfa2b: Real-world data for the treatment of PV
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A sub-analysis of the PV-ARC (NCT06134102) retrospective study evaluating real-world data from a small cohort of patients with polycythemia vera (PV) receiving ropeginterferon-alfa2b (ropegIFNα2b) has been published in Annals of Hematology by Palandri et al.1 Among 149 patients with an approved indication for ropegIFNα2b treatment, only 55 (36.9%) met the local Italian reimbursement criteria and 18 (12.1%) received ropegIFNα2b. Data from these 18 patients were analyzed based on risk status. |
| Key learnings |
| After a mean duration of 8.9 months, 66.7% of patients had a complete hematologic response (CHR) to ropegIFNα2b (CHR was higher in patients with low-risk [75%] vs high-risk [50%] PV). |
| The majority of patients (11) required dose increases, with a mean maximum dose of 131.3 µg every 2 weeks for low-risk and 120.8 µg every 2 weeks for high-risk patients. |
| RopegIFNα2b was administered in combination with hydroxyurea (HU) in 39% of patients, with the most common reason for the addition of HU being extreme thrombocytosis. |
| Larger cohorts of data in the real-world setting are required to understand optimal patient selection and management of ropegIFNα2b treatment. However, initial data highlight use of low ropegIFNα2b dose, with frequent need for hydroxyurea combinations; optimizing ropegIFNα2b dose could maximize the therapeutic benefit for patients. |
| The data support the ELN recommendation for use of ropegIFNα2b as a first-line treatment for low-risk PV. |
- Palandri F, Branzanti F, Venturi M, et al. Real-life use of ropeg-interferon α2b in polycythemia vera: patient selection and clinical outcomes. Ann Hematol. 2024;103(7):2347-2354. DOI: 1007/s00277-024-05809-6.
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