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Which factors may predict long-term outcomes with ropeginterferon alfa-2b for the treatment of PV?

During the 63rd ASH Annual Meeting and Exposition, the MPN Hub was pleased to speak to Jean-Jacques Kiladjian, Université de Paris and Hôpital Saint-Louis, Paris, FR. We asked, Which factors may predict long-term outcomes with ropeginterferon alfa-2b for the treatment of polycythemia vera (PV)?

Which factors may predict long-term outcomes with ropeginterferon alfa-2b for the treatment of PV?

Kiladjian discusses factors that are independently associated with a positive outcome with ropeginterferon alfa-2b therapy. In a cohort of patients from Hôpital Saint-Louis, two factors associated with such a potential operational cure were found: patients who received at least 2 years of ropeginterferon alfa-2b therapy with complete response, and the mutant allele burden of the JAK2 mutation. 

 

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