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Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is the only therapy that offers long term survival for accelerated-phase (AC) and blast-phase (BP) myeloproliferative neoplasms (MPN). Currently, the use of acute myeloid leukemia based intensive/non-intensive blast reduction regimens and management considerations in patients with AC and BP is not well understood.
Recently, Davidson et al.1 published a retrospective study in Blood Advances to evaluate the clinical outcomes of acute myeloid leukemia based blast reduction strategies in patients with AC/BP MPN. We summarize the key points below.
Figure 1. Percentage of patients who achieved eligibility for allo-HSCT for each treatment regimen*
Allo-HSCT, allogeneic hematopoietic stem cell transplantation; Ara-C, cytarabine; Aza, azacitidine; HD, high-dose; HMA, hypomethylating agent; Ven, venetoclax.
*Adapted from Davidson et al.1
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