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On July 19, 2022, Scientific Education Support held its first clinical trial club, entitled “BOREAS trial: Navtemadlin (KRT-232) vs best available therapy in relapsed/refractory MF.” This live webinar was part of the MPN Hub Clinical Trial Club webinar series, entitled “Novel agents for the treatment of advanced myelofibrosis.”
The live webinar aimed to discuss the phase II and phase III navtemadlin clinical trials (NCT03662126), investigating navtemadlin, a murine double minute 2 (MDM2) inhibitor, in patients with myelofibrosis (MF) who relapse on, or are refractory to, Janus kinase (JAK) inhibitors. The event was chaired by Laura Michaelis, Medical College of Wisconsin, Milwaukee, US, and presented by the trial investigator Haifa Kathrin Al-Ali, University Hospital Halle (Saale), Halle, DE.
During the webinar, Haifa Kathrin Al-Ali talked about MDM2 inhibition in MF, and presented safety and efficacy data from the phase II trial. Subsequently, the two speakers discussed what these findings, and the ongoing randomized controlled phase III BOREAS trial, mean for clinical practice, which was followed by a live Q&A session.
Clinical trial club: Navtemadlin vs best available therapy in relapsed or refractory myelofibrosis
What do the navtemadlin trials mean for clinical practice?
Overview of the navtemadlin trials (NCT03662126)
MDM2 inhibition in MF
Key phase II efficacy and safety findings
Editorial theme | The management of relapsed/refractory myelofibrosis: Part 3 – treatment options beyond JAK inhibition
There is an ongoing effort to develop novel approaches with different modes of action to fulfil an unmet need when Janus kinase...
Phase II results from KRT-232, a first-in-class MDM2 inhibitor, for R/R MF failing JAK inhibitor therapy
Janus kinase (JAK) inhibitors (JAKi) are commonly used in patients with myelofibrosis (MF), however, more than half of patients may discontinue...
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