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During ASCO and EHA 2021, the MPN Hub spoke with Ruben A Mesa, UT Health San Antonio, San Antonio, US. We asked, How does transfusion independence impact survival outcomes with momelotinib in myelofibrosis (MF)?
How does transfusion independence impact survival outcomes with momelotinib in MF?
Momelotinib is a JAKi that attenuates anemia in patients with MF. Mesa describes an analysis of the SIMPLIFY-1 study, comparing momelotinib with ruxolitinib in the frontline setting, and presents the correlation between transfusion-independent response and overall survival (OS) with momelotinib treatment.
Momelotinib improves transfusion independence and OS in patients with myelofibrosis
Momelotinib, a potent Janus kinase 1 and 2 (JAK1/2) inhibitor (JAKi) and an inhibitor of activin A receptor type I (ACVR1; also known as ALK-2), is currently being...
Novel agents to treat MF with suboptimal response to ruxolitinib: Long-term outcome with momelotinib
Janus kinase (JAK)–signal transducer and activator of transcription (STAT) pathway dysregulation is central to the pathogenesis of myelofibrosis...
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