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How should we define disease modification in MF?

Jun 27, 2022
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Learning objective: After reading this article, learners will be able to cite a new clinical development in myelofibrosis.

During the ESH 9th Translational Research Conference: Myeloproliferative Neoplasms, the MPN Hub was pleased to speak to Naveen Pemmaraju, MD Anderson Cancer Center, Houston, US. We asked, How should we define disease modification in myelofibrosis (MF)?

How should we define disease modification in MF?

Pemmaraju begins by explaining that since there is currently only one approved drug class for MF treatment (JAK inhibitors), the outcomes for patients can be variable. Pemmaraju goes on to discuss the importance of measuring disease, and how the introduction of new combination therapies could lead to new response criteria. Finally, Pemmaraju talks about a review article published in 'Cancer' earlier this year (2022), led by himself and Professor Adam J. Mead, University of Oxford, Oxford, UK.