MANIFEST study: Does the BET inhibitor CPI-0610 show synergy with ruxolitinib in myelofibrosis?

During the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, the MPN Hub spoke to Srdan Verstovsek, MD Anderson Cancer Center, Houston, US. We asked, Does the bromodomain and extraterminal domain (BET) inhibitor CPI-0610 show synergy with ruxolitinib in myelofibrosis (MF)?

The use of the JAK inhibitor ruxolitinib is standard practice for most patients with MF.However, it does not control all the systemic symptoms in all patients. In this video, Verstovsek discusses the results of the phase II MANIFEST study investigating the BET inhibitor CPI-0610 in combination with ruxolitinib in patients with MF.