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MANIFEST study: Does the BET inhibitor CPI-0610 show synergy with ruxolitinib in myelofibrosis?
Featured:
Srdan VerstovsekVideo series
During the 62nd American Society of Hematology (ASH) Annual Meeting and Exposition, the MPN Hub spoke to Srdan Verstovsek, MD Anderson Cancer Center, Houston, US. We asked, Does the bromodomain and extraterminal domain (BET) inhibitor CPI-0610 show synergy with ruxolitinib in myelofibrosis (MF)?
The use of the JAK inhibitor ruxolitinib is standard practice for most patients with MF. However, it does not control all the systemic symptoms in all patients. In this video, Verstovsek discusses the results of the phase II MANIFEST study investigating the BET inhibitor CPI-0610 in combination with ruxolitinib in patients with MF.
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This content is accurate as of the date of publication and is not updated retrospectively. Please refer to the latest available evidence, guidelines, and relevant regulatory information when making clinical decisions.
More from this series:
ASH 2020 highlights for myelofibrosis
Your opinion matters
Among patients with myelofibrosis and isolated anemia at presentation, with no indication for treatment with a JAK inhibitor, how often do you use anemia-directed treatments (EMAs, ESAs, danazol, etc.) as monotherapy?