MPN-FIT: Exercise interventions for MPN

The randomized controlled pilot MPN-FIT trial compared a 12-week supervised exercise intervention (FIT group; n = 26) with waitlist control (n = 21) in patients with myeloproliferative neoplasms (MPN). Results were published in Blood Advances by Ouellet et al. The primary objectives were to evaluate the feasibility of an individualized home-based exercise intervention; assess effects on symptoms, quality of life (QoL), and biomarkers; and explore acceptability of exercise as a method of symptom management.

Key data: The feasibility criteria were met, with 88% of FIT patients reporting satisfaction with exercise as an intervention and 92% indicating they will continue physical activity post-study. The median adherence to the prescribed exercise regimen was 81% (interquartile range [IQR], 50–100). A reduction in lactate dehydrogenase (LDH) levels was observed in the FIT group compared with the control group (−14.5 U/L vs +4.0 U/L; p = 0.03). Patients with higher baseline symptom burden (MPN symptom assessment form [MPN-SAF] score >20) demonstrated improvements in QoL (p = 0.03); this was further improved with longer exercise session duration (p = 0.016) and higher moderate-intensity exercise duration (p = 0.049).

Key learning: Supervised exercise showed improved QoL and potential benefits to inflammatory and disease markers in patients with MPN, supporting physical activity as a safe and accessible supportive care option in this population.