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Patient- vs physician-reported symptom burden in MPN: A GSG-MPN intraindividual analysis
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MPN are associated with numerous symptoms that can severely impact patient QoL and ability to conduct activities of daily living.1 Whilst previous studies have demonstrated differences in patient- vs physician-reported MPN symptom burden, studies directly comparing perception of symptom burden between matched patient and physician responses are lacking.1 Manz et al.1 conducted a retrospective analysis of data from 3,979 patients with MPN (38% ET, 33% PV, 21% PMF, and 8% other/unclassified MPN) from the GSG-MPN Bioregistry to provide an intra-individual comparison of patient- and physician-reported symptom burden, with a focus on the impact of symptom burden on OS. Patient symptom ratings were assessed using a modified MPN-SAF-TSS assessment and matched with physician assessments conducted within 3 months. Findings were published in Leukemia.1
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| Key learnings |
| 93% of patients reported the presence of ≥1 symptom at baseline, with severe disease burden reported by 38% of patients. Severe patient-reported symptoms were an independent risk factor for death. All symptoms were reported more frequently by patients than physicians. |
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Fatigue was the most commonly reported symptom by both patients and physicians. However, reports of fatigue were significantly different between patients (82% to 85%) and physicians (26% to 36%) (p < 0.001). |
| Sleep hyperhidrosis, pain, and pruritus were the second most commonly reported symptoms, followed by weight loss and fever. Pruritus was reported most commonly in PV by both patients (60%) and physicians (27%) (p < 0.001). |
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These findings suggest significant discrepancies in symptom recognition between patients and physicians (with physicians underestimating the presence of symptoms) and demonstrate the association of severe patient-reported outcomes with survival, highlighting the need for careful patient-reported symptom assessment using validated tools, both in routine clinical practice and clinical trials. |
Abbreviations: ET, essential thrombocytosis; GSG-MPN, German Study Group for Myeloproliferative Neoplasms; MPN, myeloproliferative neoplasms; MPN-SAF-TSS, Myeloproliferative Neoplasm Symptom Assessment Form Total Symptom Score; OS, overall survival; PMF, primary myelofibrosis; PV, polycythemia vera.
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