Reconsidering the place of BMT, BMT reporting consistency, and Q&A

During the MPN Hub Steering Committee Meeting in May 2024, key opinion leaders met to discuss the place of bone marrow transplant (BMT), and BMT reporting consistency. Alessandro Vannucchi delivered a presentation on use of BMT in myelofibrosis (MF), including strategies to optimize the outcomes of BMT and considerations to be made for special populations.

Vannucchi discusses the increase trend for the use of allogenic hematopoietic stem cell transplant (allo-HSCT) in patients as well as the age of patients with MF who may be eligible. They highlight the importance of considering the risks and benefits of transplant, consideration comorbidities, and early transplant where possible. They also highlight how to optimize transplant outcomes, discussing the role of splenomegaly and management, as well as post-transplant monitoring. This presentation concludes with a discussion on the impact of TP53 mutations and accelerated vs blast phase MF in special populations.

Q&A

Following their presentation, Vannucchi chaired a Q&A session featuring Steering Committee members Laura Michaelis, Haifa Kathrin Al-Ali, Tiziano Barbui, Steffen Koschmieder, Chloe James, and guest speaker Benjamin Rolles. Discussions include how mutations, such as ASXL1, may impact selecting BMT and ruxolitinib in the first line, and how it could be used prior to BMT to prevent GvHD.