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Over the past two decades, the therapeutic landscape of myeloproliferative neoplasms (MPN) has rapidly evolved in conjunction with innovative research and pioneering clinical trials. Identification of the key driver mutation in the JAK2 gene represented a milestone in the development of disease-specific therapies. As a result, patients now have access to four Janus kinase inhibitors for the treatment of myelofibrosis, with momelotinib most recently approved in September 2023. Furthermore, interferon treatments and specific cytoreductive therapies have improved clinical outcomes for patients diagnosed with essential thrombocythemia and polycythemia vera.
To showcase the progression of treatment options over the past 20 years, we present a visual summary of approvals for common therapies used in MPN treatment (Figure 1).
Figure 1. Timeline of drug approvals in MPN
1 March 14th 1997, 2 May 24th 2000, 3 January 19th 2001, 4 June 20th 2002, 5 October 16th 2002, 6 August 29th 2004, 7 November 16th 2004, 8 June 29th 2007, 9 November 16th 2011, 10 August 23rd 2012, 11 December 4th 2014, 12 August 16th 2019, 13 February 2021, 14 February 28th 2022, 15 September 15th 2023
EMA, European Medicines Agency; FDA, U.S. Food and Drug Administration; IFN, interferon; JAK, Janus kinase; MF, myelofibrosis: OOD, orphan drug administration; PV, polycythemia vera.