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An expert panel hosted by
Customizing first-line BTK inhibitors for CLL
with Gilles Salles, Paolo Ghia, and Francesc Bosch
Wednesday, October 23, 2024
18:30-19:30 BST
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Patients with myelofibrosis (MF) are more likely to experience fibrotic changes which can impact the bone marrow (BM) niche, and result in impaired hematopoiesis, anemia, and thrombocytopenia. Zinpentraxin alfa is a recombinant form of the human pentraxin-2 which possesses antifibrotic activity and is being investigated in the treatment of MF.
Here, we summarize a study published by Verstovsek et al.1 in Haematologica on results from the randomized phase II trial (NCT01981850) of zinpentraxin alfa in patients with MF who are ineligible for, intolerant of, or had an inadequate response to ruxolitinib.
Figure 1. BM improvement by cohort*
BM, bone marrow.
*Adapted from Verstovsek, et al.1
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