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Managing anemia in patients with MF

Sep 21, 2026

Learning objective: After reading this article, learners will be able to describe the burden of MF-related anemia, the clinical evidence supporting emerging treatment approaches, including luspatercept, and their role in contemporary management.


Do you know... In myelofibrosis (MF)-related anemia, which statement best describes the role of luspatercept?

Anemia is present in approximately 45% of patients with myelofibrosis (MF) at diagnosis and becomes increasingly common as the disease progresses.1 It is associated with reduced quality of life, red blood cell (RBC) transfusion dependence, and inferior survival.1 Despite advances in MF management, anemia remains a major unmet clinical need, driving the development of targeted therapies such as luspatercept.1–3 

We summarize the burden of MF-related anemia, the mechanism of action of luspatercept, and key findings from the INDEPENDENCE, and ODYSSEY clinical trials, highlighting the evolving role of targeted approaches in the management of MF-related anemia.4,5 

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This educational resource is independently supported by BMS. All content is developed by SES in collaboration with an expert steering committee. Funders are allowed no influence. 

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