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On November 21, 2023, topline results were released from the phase III MANIFEST-2 trial (NCT04603495) investigating pelabresib, a bromodomain and extra-terminal domain inhibitor, in combination with ruxolitinib vs placebo for Janus kinase inhibitor-naïve patients with myelofibrosis.
The study met its primary endpoint of spleen volume reduction ≥35% (SVR35) at Week 24 for patients treated with combination therapy. Significant improvements in secondary endpoints were also observed, including change in Total Symptom Score (TSS) and ≥50% reduction in TSS at Week 24 in both intermediate-risk patients (90% of cohort) and the overall patient cohort.
To learn more about current combination therapies for Janus kinase inhibitor-naïve patients with myelofibrosis, read our recent MPN Hub article.
Figure 1. Absolute TSS change in patients with intermediate-risk disease and the overall patient cohort*
TSS, Total Symptom Score.
*Adapted from MorphoSys.1
Combination therapy was also favorable in ≥50% reduction in TSS for both intermediate-risk patients and the overall patient cohort compared with placebo (Figure 2).
Figure 2. TSS50 in patients with intermediate-risk disease and the overall patient cohort*
TSS50, ≥50% reduction in Total Symptom Score.
*Adapted from MorphoSys.1
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