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The MPN Hub were pleased to speak to John Mascarenhas, Icahn School of Medicine at Mount Sinai, New York, US, during the 61st American Society of Hematology Meeting & Exposition in Orlando, US. Based on the MANIFEST study, we asked: Should the bromodomain and extraterminal domain inhibitor (BETi), CPI-0610, be used as an add-on to ruxolitinib for symptom control in patients with advanced myelofibrosis (MF)?
John Mascarenhas discusses the MANIFEST study of the BETi, CPI-0610, in patients with myelofibrosis. He discusses the study enrollment criteria, primary endpoints, the treatment regimen and the overall patient outcomes. He also describes the preclinical data and the rationale for the study.
MANIFEST study: Should CPI-0610 be used as an add-on to ruxolitinib in patients with advanced MF?
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