Secreted mutant calreticulins as rogue cytokines in myeloproliferative neoplasms

The MPN Hub invited Stefan Constantinescu, De Duve Institute, Brussels, BE, to give a presentation and chair a discussion on his research paper: Secreted mutant calreticulins (CALRs) as rogue cytokines in myeloproliferative neoplasms. MPN Hub Steering Committee members Jean-Jacques Kiladjian, Steffen Koschmieder, Haifa Kathrin Al-Ali, Tiziano Barbui, and Laura Michaelis joined the discussion.

Constantinescu opens by providing a background on mutant CALRs and outlining the key questions this international study aimed to answer, including whether mutant CALRs are secreted and from which cells.¹ Constantinescu goes on to review the results data and the implications the findings may have on future research in myeloproliferative neoplasms. Following this presentation, the committee members discuss the study and the unanswered questions remaining around mutant CALRs.