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Treatment sequencing for anemic myelofibrosis
with Jean-Jacques Kiladjian & Angela Fleischman
Monday, February 26, 2024 | 16:30 CET
This independent educational activity is supported by Bristol Myers Squibb. All content is developed independently by the faculty. The funder is allowed no influence on the content of this activity.
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On November 1, 2022, the European Commission granted orphan drug designation to selinexor for the treatment of patients with myelofibrosis.1 Earlier this year, on May 26, 2022, the U.S. Food and Drug Administration (FDA) granted the same designation.
Selinexor is a first-in-class oral exportin 1 (XPO1) inhibitor; inhibition of the exportin protein stops tumor suppressor, growth regulatory, and anti-inflammatory proteins being transported from the cell nucleus to the cell cytoplasm (Figure 1).1 The subsequent buildup of these proteins within the cell nucleus results in anticancer activity, as well as a counteraction of any active oncogenic signaling.1 There are currently three ongoing clinical trials investigating selinexor in myelofibrosis, which we summarize below.
Figure 1. Selinexor mechanism of action*
eIF4E, eukaryotic translation initiation factor 4E; XPO1, exportin 1.
*Adapted from Karyopharm Theraputics.2 Created with BioRender.com.
The ESSENTIAL trial (NCT03627403) is a single-arm, phase II study evaluating selinexor monotherapy for patients diagnosed with primary myelofibrosis, post-essential thrombocytosis, or post-polycythemia vera who have had previous exposure to ruxolitinib or another JAK inhibitor. Prior to study protocol version 7, patients were orally administered 60 mg or 80 mg selinexor once a week until disease progression, toxicity, or no sign of clinical benefit. Any patients enrolled after protocol version 7 will be administered selinexor orally, beginning at 40 mg once per week. The primary endpoint of the study has been set at changes in spleen volume. Secondary endpoints are changes in symptom score, overall survival, overall response rate, and safety. Data from the first 12 patients enrolled in this trial were presented at the 63rd American Society of Hematology (ASH) Annual Meeting and Exposition in 2021; check out this previous MPN Hub article for a summary.
A randomized phase II trial (NCT04562870) is investigating the safety and efficacy of selinexor compared with the treatment choice of a clinician in patients diagnosed with myelofibrosis who have had ≥6 months prior treatment with a JAK inhibitor. The primary endpoint of the study has been set as the percentage of patients with a reduction in spleen volume ≥35%. Secondary endpoints include overall survival, overall response rate, and the percentage of patients with a reduction in total symptom score ≥50%.4 This trial is estimated to enroll a total of 112 patients.4
A global phase I/II study (NCT04562389) is investigating selinexor in combination with ruxolitinib for the treatment of patients diagnosed with myelofibrosis who have received no prior related therapy. The phase Ia section of the study aims to establish the recommended phase II dosing, as well as generate initial safety and efficacy data through a 3 + 3 trial design. The phase Ib section of the study will further evaluate the recommended phase II dosing and provide additional safety and efficacy findings. The full trial design is shown in Figure 2. During the phase II part of the study, patients will be randomly assigned either the combination therapy or ruxolitinib alone. Data from this trial is set to be presented at the 64th ASH Annual Meeting and Exposition on December 10–13, 2022, in New Orleans, US.5
Figure 2. NCT04562389 trial design*
BID, twice a day; MF, myelofibrosis; PO, orally; RP2D, recommended phase II dose; RUX, ruxolitinib; SEL, selinexor.
*Adapted from ClinicalTrials.gov.6
†Cohort 1 received SEL 40 mg PO.
‡Cohort 2 received SEL 60 mg PO.
§Cohort −1 received SEL 20 mg PO twice weekly.
Current combination therapies in MPN
Here, we summarize a presentation by John Mascarenhas on the status of combination therapies in MPN from the 15th International Congress on MPN.
ASH2023 abstracts: What’s hot in MPN?
To help navigate the exciting content being presented at the 65th ASH Annual Meeting and Exposition, the MPN Hub Steering Committee have provided their recommendations for the top abstracts to look out for in MPN.
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