Should patients with myelofibrosis be transplanted before or after ruxolitinib failure?

During the 47th Annual Meeting of the European Society for Blood and Marrow Transplantation (EBMT), the MPN Hub spoke to Nicolaus Kröger, University Medical Center Hamburg-Eppendorf, Hamburg, DE. We asked, Should patients with myelofibrosis be transplanted before or after ruxolitinib failure?

Ruxolitinib is a JAK1/2 inhibitor used to reduce spleen size and improve constitutional symptoms before transplantation. In this video, Kröger details when allogeneic stem cell transplantation should be performed in patients with myelofibrosis who have received treatment with ruxolitinib, based on available data from clinical trials.