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2024-07-12T08:34:18.000Z

Visual abstract | ROP-ET: Ropeginterferon alfa-2b for ET with limited treatment options

Jul 12, 2024
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Learning objective: After reading this article, learners will be able to cite a new clinical development in essential thrombocythemia with limited treatment options.

Test your knowledge! Take our quick quiz before and after you read this article to find out if you improved your knowledge. Results help us to improve content and continually provide open-access education.

Common treatments for the management of essential thrombocythemia (ET) include hydroxyurea, anagrelide, busulfan, and pipobroman. However, an increasing number of patients are experiencing intolerance, resistance, or comorbidities to these treatments, significantly limiting their available options going forward 

Ropeginterferon alfa-2b has shown efficacy in the treatment of polycythemia vera and is now being further investigated for its application in ET as part of the ROP-ET clinical trial. ROP-ET is a prospective, single-arm, phase III clinical trial evaluating ropeginterferon alfa-2b for the treatment of ET with limited treatment options. 

The rationale and design for ROP-ET has recently been published in Annals of Hematology by Kiladjian et al. 1

The MPN Hub is pleased to summarize the study design of ROP-ET. 



 




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