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Visual abstract | ROP-ET: Ropeginterferon alfa-2b for ET with limited treatment options
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What is the primary endpoint for the ROP-ET clinical trial?
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Common treatments for the management of essential thrombocythemia (ET) include hydroxyurea, anagrelide, busulfan, and pipobroman. However, an increasing number of patients are experiencing intolerance, resistance, or comorbidities to these treatments, significantly limiting their available options going forward.
Ropeginterferon alfa-2b has shown efficacy in the treatment of polycythemia vera and is now being further investigated for its application in ET as part of the ROP-ET clinical trial. ROP-ET is a prospective, single-arm, phase III clinical trial evaluating ropeginterferon alfa-2b for the treatment of ET with limited treatment options.
The rationale and design for ROP-ET has recently been published in Annals of Hematology by Kiladjian et al. 1
The MPN Hub is pleased to summarize the study design of ROP-ET.
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