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What implications might the PERSIST-2 landmark OS analysis data have on the use of pacritinib in MF?

Jul 19, 2023
Learning objective: After reading this article, learners will be able to cite a new clinical development in myelofibrosis.

During the 2023 American Society of Clinical Oncology (ASCO) Annual Meeting, the MPN Hub was pleased to speak to Helen Ajufo, Memorial Sloan Kettering Cancer Center, New York, US. We asked, What implications might the PERSIST-2 landmark overall survival (OS) analysis data have on the use of pacritinib in myelofibrosis?

What implications might the PERSIST-2 landmark OS analysis data have on the use of pacritinib in MF?

In this interview, Ajufo shares insights on the latest analysis from the PERSIST-2 trial on spleen reduction as a predictor of OS in pacritinib-treated myelofibrosis. Ajufo discusses the OS data, stratified by patient platelet count and spleen volume reduction achieved, making comparisons with corresponding data from the control arm of best available therapy. This interview concludes with a look at the future application of pacritinib in myelofibrosis.

For more information on pacritinib and the PERSIST-2 trail, visit our previous coverage from ASCO and EBMT.


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