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LIMBER: Safety and tolerability of INCB057643 in patients with MF and other advanced MPN
Do you know... What was the most common TEAE in the LIMBER trial of INCB057643 in patients with MF and other MPN?
Bromodomain and extra-terminal (BET) proteins regulate expression of oncoproteins central to the pathophysiology of several hematologic malignancies, including myelofibrosis (MF) and other myeloproliferative neoplasms (MPN), making BET inhibitors (BETi) an important area of research for patients with such malignancies.
Here, we present a visual abstract outlining the trial design and summarizing key efficacy and safety data to date from the phase I LIMBER (NCT04279847) trial evaluating INCB057643, an oral, small-molecule BETi, as monotherapy in adults with relapsed/refractory MF, essential thrombocythemia, myelodysplastic syndromes, or myelodysplastic syndrome / myeloproliferative neoplasm overlap syndromes, or as combination therapy with ruxolitinib in adults with MF and a suboptimal response to ruxolitinib.
This educational resource is independently supported by Incyte. All content was developed by SES in collaboration with an expert steering committee. Funders were allowed no influence on the content of this resource.
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A 68-year-old male with primary myelofibrosis received ruxolitinib 10 mg twice daily for 7 months. His spleen size and symptoms are controlled, but Hb remains <8 g/dL. EPO, 210 mU/mL; platelets, 85,000/µL. What is your next step?
