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Ruxolitinib for the treatment of MF in clinical routine: Initial results from a phase IV study
Results from the phase IV non-interventional JAKoMo trial (NCT05044026) evaluating real-world ruxolitinib treatment outcomes in 943 patients with myelofibrosis (MF) (Arm A, ruxolitinib-naïve patients, n = 479; Arm B, ruxolitinib-experienced patients, n = 464) were published by Koschmieder et al. in the European Journal of Haematology.
Key data
- Ruxolitinib-naïve patients showed rapid (≤6 months), sustained improvements in spleen length (mean decrease from 19.0 cm to 16.89 cm at 12 months), constitutional symptoms, and quality of life (QoL) measures (~17% increase in the proportion of patients experiencing normal German QoL during follow-up in both arms).
- Adverse events (AEs) were less frequent than in registrational trials, with lower rates of anemia (24% vs 32%), reduced hemoglobin (7% vs 12%), and thrombocytopenia (12% vs 29%) in ruxolitinib-experienced vs -naïve patients.
- OS at 36 months (75%) was comparable to phase III COMFORT trial data.
Key learning
Real-world ruxolitinib treatment demonstrates significant and sustained clinical benefits for patients with MF, with maximum responses achieved within 6 months, supporting more conservative dosing strategies that maintain efficacy while potentially reducing AEs compared with clinical trial protocols.
References
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This content is accurate as of the date of publication and is not updated retrospectively. Please refer to the latest available evidence, guidelines, and relevant regulatory information when making clinical decisions.
Your opinion matters
Among patients with myelofibrosis and isolated anemia at presentation, with no indication for treatment with a JAK inhibitor, how often do you use anemia-directed treatments (EMAs, ESAs, danazol, etc.) as monotherapy?
