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Phosphatidylinositol-3-kinase (PI3K) signaling pathway plays a crucial role in B cell activation, differentiation, and survival. It also regulates cell growth, motility, survival, metabolism, and angiogenesis, and contributes to development of tumors and drug-resistance. PI3K inhibitors, like idelalisib and alpelisib, cause cell death and inhibit the proliferation of malignant cells.